The quarterfinals of the Clausura 2023 Liga MX final phase feature eight teams, including the two teams mentioned above.
San Luis have a difficult assignment in the second leg to reverse the trend after America defeated them 3-1 in the first round.
The home team is considered the overwhelming favorite to win the second leg. America avoided playing Reclassification to advance directly to the quarterfinals.
Aguillas qualified for the quarterfinals of the final phase after placing second in the Clausura regular season, six points behind Monterrey (40). America was eliminated by eventual champions Pachuca in the semifinals of the previous campaign.
Meanwhile, San Luis stunned Leon 3-1 in the Reclassification to go to the quarterfinals. With 19 points, they placed 12th during the regular season.
The visitors haven't won the championship yet, but manager André Jardine believes they have as good a chance as ever this year to make history.
Los Atleticos are attempting to overcome the 3-1 lead, but it will be difficult given their dismal road record.
Their last trip to the Estadio Azteca ended in a 3-0 loss, and they have only won one of their last five road games. But they triumphed there in February 2022, 3-2.